From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Mitochondrial import inner membrane translocase subunit Tim9 is an enzyme that in humans is encoded by the TIMM9 gene .[5] [6] [7]
TIMM9 belongs to a family of evolutionarily conserved proteins that are organized in heterooligomeric complexes in the mitochondrial intermembrane space .
These proteins mediate the import and insertion of hydrophobic membrane proteins into the mitochondrial inner membrane .[supplied by OMIM][7]
References [ edit ]
^ a b c GRCh38: Ensembl release 89: ENSG00000100575 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021079 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Jin H, Kendall E, Freeman TC, Roberts RG, Vetrie DL (Feb 2000). "The human family of Deafness/Dystonia peptide (DDP) related mitochondrial import proteins". Genomics . 61 (3): 259–67. doi :10.1006/geno.1999.5966 . PMID 10552927 .
^ Muhlenbein N, Hofmann S, Rothbauer U, Bauer MF (Mar 2004). "Organization and function of the small Tim complexes acting along the import pathway of metabolite carriers into mammalian mitochondria" . J Biol Chem . 279 (14): 13540–6. doi :10.1074/jbc.M312485200 . PMID 14726512 .
^ a b "Entrez Gene: TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)" .
Further reading [ edit ]
Webb CT, Gorman MA, Lazarou M, et al. (2006). "Crystal structure of the mitochondrial chaperone TIM9.10 reveals a six-bladed alpha-propeller" . Mol. Cell . 21 (1): 123–33. doi :10.1016/j.molcel.2005.11.010 . PMID 16387659 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 . PMID 15489334 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 .
Vial S, Lu H, Allen S, et al. (2002). "Assembly of Tim9 and Tim10 into a functional chaperone" . J. Biol. Chem . 277 (39): 36100–8. doi :10.1074/jbc.M202310200 . PMID 12138093 .
Rothbauer U, Hofmann S, Mühlenbein N, et al. (2001). "Role of the deafness dystonia peptide 1 (DDP1) in import of human Tim23 into the inner membrane of mitochondria" . J. Biol. Chem . 276 (40): 37327–34. doi :10.1074/jbc.M105313200 . PMID 11489896 .
Bauer MF, Rothbauer U, Mühlenbein N, et al. (2000). "The mitochondrial TIM22 preprotein translocase is highly conserved throughout the eukaryotic kingdom" . FEBS Lett . 464 (1–2): 41–7. doi :10.1016/S0014-5793(99)01665-8 . PMID 10611480 .